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2, P. In those cases in which naïve cells were anergized, a strong TCR signal was required, such as several days of stimulation with anti-CD3 on a plate in the experiments of Lechler and colleagues, or addition of certain forms of co-stimulation by Webb and colleagues. Whether this structural rearrangement activates Ang or merely ensures its specificity is unknown. Thus, as we see in Figure 9-7, the bonding MOs in the NO molecule have more oxygen- like atomic orbital character, and the antibonding orbitals have more nitrogen-like atomic orbital character.
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