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6 Reinforcement 1. 31 becomes: 'c. area A tCA, (normal kinetics); area A B C tCA0 (abnormal kinetics) fA 17.

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324 7,720 3,780 45 4,860 68 6,060 90 9,060 150 5,670 60 7,290 90 9,090 120 7,560 12,570 240 16,530 368 21,840 533 27,870 750 34,650 1,020 42,150 1,200 50,400 1,650 59,400 2,250 69,120 3,000 79,560 3,300 13,590 200 18,855 320 24,795 490 32,760 710 41,805 1,000 51,975 1,360 63,225 1,600 75,600 2,200 89,100 3,000 9,720 12,120 18,120 25,140 33,060 43,680 55,740 69,300 84,300 102,690 4,770 128,760 6,600 157,770 8,880 189,720 11,580 103,680 4,000 119,340 4,400 154,035 6,360 193,140 8,800 236,655 11,840 264,580 15,440 100,800 118,800 138,240 159,120 205,380 257,520 315,540 379,440 Table continued on next page.

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The error mean square, MSE 14 SSE n2 (a) Hereditary retinoblastoma RB RB Somatic retinal cell (b) Sporadic retinoblastoma RB RB Homozygous cell gives rise to tumors in retina Somatic mutation RB RB Somatic retinal cell 1st somatic mutation RB RB 2d RB RB somatic mutation Homozygous cell gives rise to tumors in retina FIGURE 23-10 Role of spontaneous somatic mutation in retinoblastoma.

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